Capabilities and applications of the Program to Optimize Simulated Trajectories (POST). Program summary document

The capabilities and applications of the three-degree-of-freedom (3DOF) version and the six-degree-of-freedom (6DOF) version of the Program to Optimize Simulated Trajectories (POST) are summarized. The document supplements the detailed program manuals by providing additional information that motivates and clarifies basic capabilities, input procedures, applications and computer requirements of these programs. The information will enable prospective users to evaluate the programs, and to determine if they are applicable to their problems. Enough information is given to enable managerial personnel to evaluate the capabilities of the programs and describes the POST structure, formulation, input and output procedures, sample cases, and computer requirements. The report also provides answers to basic questions concerning planet and vehicle modeling, simulation accuracy, optimization capabilities, and general input rules. Several sample cases are presented

Fixed-base simulation evaluation of various low-visibility landing systems for helicopters

Fixed base simulation evaluation of one fully automatic and six manual low visibility landing systems for helicopter

Golabi-Ito-Hall syndrome results from a missense mutation in the WW domain of the PQBP1 gene

Background: Golabi, Ito, and Hall reported a family with X linked mental retardation (XLMR), microcephaly, postnatal growth deficiency, and other anomalies, including atrial septal defect, in 1984.Methods: This family was restudied as part of our ongoing study of XLMR, but significant linkage to X chromosome markers could not be found. Extreme short stature and microcephaly as well as other new clinical findings were observed. Mutations in the polyglutamine tract binding protein 1 gene (PQBP1) have recently been reported in four XLMR disorders (Renpenning, Hamel cerebro-palato-cardiac, Sutherland-Haan, and Porteous syndromes) as well as in several other families. The clinical similarity of our family to these patients with mutations in PQBP1, particularly the presence of microcephaly, short stature, and atrial septal defect, prompted examination of this gene.Results: A missense mutation in PQBP1 was identified which changed the conserved tyrosine residue in the WW domain at position 65 to a cysteine (p.Y65C).Conclusions: This is the first missense mutation identified in PQBP1 and the first mutation in the WW domain of the gene. The WW domain has been shown to play an important role in the regulation of transcription by interacting with the PPxY motif found in transcription factors. The p.Y65C mutation may affect the proper functioning of the PQBP1 protein as a transcriptional co-activator

Aircraft control system

An aircraft control system is described which is particularly suited to rotary wing aircraft. Longitudinal acceleration and course rate commands are derived from a manual control stick to control translational velocity of the aircraft along a flight path. In the collective channel the manual controls provide vertical velocity commands. In the yaw channel the manual controls provide sideslip or heading rate commands at high or low airspeeds, respectively. The control system permits pilots to fly along prescribed flight paths in a precise manner with relatively low work load

Age at quitting smoking as a predictor of risk of cardiovascular disease incidence independent of smoking status, time since quitting and pack-years

BACKGROUND Risk prediction for CVD events has been shown to vary according to current smoking status, pack-years smoked over a lifetime, time since quitting and age at quitting. The latter two are closely and inversely related. It is not known whether the age at which one quits smoking is an additional important predictor of CVD events. The aim of this study was to determine whether the risk of CVD events varied according to age at quitting after taking into account current smoking status, lifetime pack-years smoked and time since quitting. FINDINGS We used the Cox proportional hazards model to evaluate the risk of developing a first CVD event for a cohort of participants in the Framingham Offspring Heart Study who attended the fourth examination between ages 30 and 74 years and were free of CVD. Those who quit before the median age of 37 years had a risk of CVD incidence similar to those who were never smokers. The incorporation of age at quitting in the smoking variable resulted in better prediction than the model which had a simple current smoker/non-smoker measure and the one that incorporated both time since quitting and pack-years. These models demonstrated good discrimination, calibration and global fit. The risk among those quitting more than 5 years prior to the baseline exam and those whose age at quitting was prior to 44 years was similar to the risk among never smokers. However, the risk among those quitting less than 5 years prior to the baseline exam and those who continued to smoke until 44 years of age (or beyond) was two and a half times higher than that of never smokers. CONCLUSIONS Age at quitting improves the prediction of risk of CVD incidence even after other smoking measures are taken into account. The clinical benefit of adding age at quitting to the model with other smoking measures may be greater than the associated costs. Thus, age at quitting should be considered in addition to smoking status, time since quitting and pack-years when counselling individuals about their cardiovascular risk.This research was supported by an NHMRC health services research grant (no. 465130), an NHMRC/NHF PhD scholarship and a Vichealth Fellowship

Concept design and alternate arrangements of orbiter mid-deck habitability features

The evaluations and recommendations for habitability features in the space shuttle orbiter mid-deck are summarized. The orbiter mission plans, the mid-deck dimensions and baseline arrangements along with crew compliments and typical activities were defined. Female and male anthropometric data based on zero-g operations were also defined. Evaluations of baseline and alternate feasible concepts provided several recommendations which are discussed

Gravitational settling of 22Ne and white dwarf evolution

We study the effects of the sedimentation of the trace element 22Ne in the cooling of white dwarfs. In contrast with previous studies, which adopted a simplified treatment of the effects of 22Ne sedimentation, this is done self-consistently for the first time, using an up-to-date stellar evolutionary code in which the diffusion equation is coupled with the full set of equations of stellar evolution. Due the large neutron excess of 22Ne, this isotope rapidly sediments in the interior of the white dwarf. Although we explore a wide range of parameters, we find that using the most reasonable assumptions concerning the diffusion coefficient and the physical state of the white dwarf interior the delay introduced by the ensuing chemical differentation is minor for a typical 0.6 Msun white dwarf. For more massive white dwarfs, say M_Wd about 1.0 Msun, the delay turns out to be considerably larger. These results are in qualitatively good accord with those obtained in previous studies, but we find that the magnitude of the delay introduced by 22Ne sedimentation was underestimated by a factor of about 2. We also perform a preliminary study of the impact of 22Ne sedimentation on the white dwarf luminosity function. Finally, we hypothesize as well on the possibility of detecting the sedimentation of 22Ne using pulsating white dwarfs in the appropriate effective temperature range with accurately determined rates of change of the observed periods.Comment: To apper in The Astrophysical Journa

Improving the Performance of Single Chip Image Capture Devices

Single chip charge-coupled devices (CCDs) coupled with filters for isolating red, green, and blue color content are commonly used to capture color images. While this is more cost effective than multiple chip systems, best results are obtained when full RGB color information is obtained for every point in an image. The process of color subsampling in a single chip system degrades the resulting image data by introducing artifacts such as blurry edges and false coloring. We propose an algorithm for enhancing color image data that were captured with a typical single chip CCD array. The algorithm is based on stochastic regularization using a Markov random field model for the image data. This results in a constrained optimization problem, which is solved using an iterative constrained gradient descent computational algorithm. Results of the proposed algorithm show a marked improvement over the original sampled image data

Humanistic Criminology: Roots from Peter Kropotkin

Kropotkin\u27s extensive writings on criminological issues have been almost totally neglected. Through critical historical and macro-structural analyses Kropotkin assessed institutional arrangements disclosing how they were or were not meeting human needs. Our exploration focuses on Kropotkin\u27s theoretical contributions, his feelings-based criminology and his extremely insightful dualistic conceptualization of human nature . His contributions to penology, and his assessment of social arrangements which would meet the complex and ever-changing needs of humankind are briefly examined. Kropotkin\u27s analytic framework provides an insightful and provocative base from which to synthesize criminological thought and research and from which to take action to alter social arrangements which do not meet human needs